Six fire engines and at least 40 firefighters were called to a fire at a house in Sandycoombe Road in Twickenham this afternoon.
The ground floor of the property, half of the first floor and half of the roof were alight.
Fire crew will remain on the scene this evening.
Motorists are warned to avoid the area if possible as road closures are in place.
A London Fire Brigade spokesman said: "The Brigade was called at 1.50pm.
"Fire crews from Heston, Twickenham, Richmond and Kingston fire stations are at the scene."
The cause of the fire is not known at this stage.
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