Drivers are being warned to avoid the A305, which has been shut due to an crash in Fullwell.
Staines Road is closed between Hospital Bridge Road and Twining Avenue after a crash at Fielding Avenue.
Bus routes 110, 490 and H22 are on diversion both ways due to the incident by Sixth Cross Road in Hanworth, near Fulwell Golf Course.
Transport for London said passengers should expect some delays and people should allow some extra time for journeys.
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