Rashid Mullahzadah, who has Middlesex second eleven experience, claimed 6-43 and spinner Parminder Singh 3-22 as Brondesbury were dismissed for 109.
And Carlos Nunes' men needed just 18 overs to secure the win as Eugene Burger (588) hit a second successive half century to lead his side to victory.
The result moved Twickenham up to second in the table after borough rivals Richmond held Ealing to a dramatic winning draw at Old Deer Park.
The visitors plodded to 241 for seven as spinner Tom Hemingway (3-36) and opening bowler Dave Burton (3-71) put the brakes on the former champions.
And Richmond had Alex Griffiths (81*) and Burton (55*) to thank for the four points as their unbeaten 120-run sixth wicket partnership saw the scores finish level.
League leaders Teddington remain top despite a nine wicket thrashing by Hampstead at Bushy Park.
Only James Wade (40) showed any resistance as Mubasher Hassan claimed 6-13 in seven overs to help dismiss the hosts for just 66.
Hampstead had no trouble easing to victory.