Nick Kennedy will make his senior starting debut when Harlequins take on ASM Clermont Auvergne in round five of the Heineken Cup this afternoon at The Twickenham Stoop
The 32-year-old will partner George Robson in the second row.
Ugo Monye and Danny Care return to the back line, while Luke Wallace is named at blindside flanker.
Among the replacements, Joe Gray returns from injury to provide cover for Dave Ward, while Karl Dickson will look to make his 100th appearance for the club.
Kick-off is at 1.35pm, live on Sky Sports 1.
Harlequins: Mike Brown, Charlie Walker, Matt Hopper, Tim Molenaar, Ugo Monye, Nick Evans, Danny Care, Joe Marler, Dave Ward, Will Collier, Nick Kennedy, George Robson, Luke Wallace, Chris Robshaw, Nick Easter, Joe Gray, Mark Lambert, Paul Doran Jones, Charlie Matthews, Tom Guest, Karl Dickson, Ben Botica, Ollie Lindsay-Hague.